what is tnt in medical terms

No statistically significant findings were observed between patients who received TNT and standard treatment (OR, 1.04; 95% CI, 0.711.53; p=.85; Fig. As for DFS and DMFS, subgroup analysis was not performed because of the limited availability. Multiple trials and metaanalysis appear to demonstrate that shortcourse radiotherapy and longcourse radiotherapy are roughly equal in terms of local control [40, 41, 42, 43, 44, 45]. Nahas SC, Rizkallah Nahas CS, Sparapan Marques CF et al. What does TNT stand for in Veterinary? Analysis for (A) diseasefree survival, (B) overall survival, (C) local recurrencefree survival, and (D) distant metastasisfree survival are shown. Browse the list of 859k Medical acronyms and abbreviations with their meanings and definitions. Lab results below the 99th percentile mean normal function. As a library, NLM provides access to scientific literature. What's in a Name? Relatedly, the radiotherapy dose fraction method also impacts the pCR rate. CAH to DPT. Guangzhou What is a TVT or TOT procedure? Hear a word and type it out. If they see an increase in the troponin level on the repeat test, thats an indication of heart muscle damage. The most common use of troponin tests is to confirm or rule out a heart attack. (Most of the time.). (2019). and T.J.) used a standardized form to independently extract the summaries, clinical outcomes, and study data (the study's authors, publication year, patient categories, age, gender, clinical stage, oncologic performance scale, study design, therapeutic regimens, sample size, and the distance between the tumor and the anal verge). The unit of exposure most often used is the roentgen. The meaning of TRINITROTOLUENE is tnt. While Roswell Park strives to provide accessibility and usability for all users, please be aware that accessibility is an ongoing effort, and it may not be possible in all areas of Roswell Parks Services with current technology and other restrictions. The latest information about heart & vascular disorders, treatments, tests and prevention from the No. 10 Things People With Depression Wish You Knew Shot-Free MS Treatment Your Child and COVID-19 Self-diagnosis is never recommended. Delivered to your inbox! Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imagingdefined, locally advanced rectal cancer: Grupo Cncer de Recto 3 study. Secondary endpoints were diseasefree survival (DFS), overall survival (OS), local recurrencefree survival, distant metastasisfree survival, and the R0 resection rate. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yatsen University, If your cancer care team determines that TNT is the best approach for you, most or all of your cancer therapy will be neoadjuvant, meaning that it is delivered before surgery. Get useful, helpful and relevant health + wellness information. Higher levels could mean a heart attack or another. Supplemental Table 1 MEDLINE search strategy. Detailed risk information is provided in supplemental online Figure1. What does TNT mean? Cleveland Clinic is a non-profit academic medical center. As for postoperative chemotherapy, the National Comprehensive Cancer Network guidelines recommend TME should be followed by adjuvant systemic chemotherapy; however, less than 50% of eligible patients receive their scheduled adjuvant chemotherapy due to delays, treatment compliance, and postoperative complications [5, 6]. There was no obvious evidence of publication bias. Medical TNT abbreviation meaning defined here. The primary endpoint was pathologic complete response (pCR). Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. Other conditions that can cause your troponin levels to increase include: This test sees most of its use in hospital emergency rooms when medical professionals suspect a recent heart attack. For survival outcomes, TNT treatment showed improvements in DFS and DMFS compared with standard CRT (HR, 0.83; 95% CI, 0.720.96, p=.03 and HR, 0.81; 95% CI, 0.680.95; p=.012; Fig. In most cases, there are minimal or no side effects from this test. Exposure pathway: a route by which a radionuclide or other toxic material can enter the body. noun Data produced by a computer in response to a command. Federal government websites often end in .gov or .mil. Tarsometatarsal. CCCT, or CCT: Clomiphene Citrate Challenge Test, a fertility test. This work was supported by the 5010 Clinical Research Foundation of Sun Yatsen University (Grant 5010201804). It is commonly known as TNT and is an explosive used in military shells, bombs, and grenades, in industrial uses, and in underwater blasting. FernndezMartos C, Pericay C, Aparicio J et al. For detailed patient characteristics of each trial, see Table2. CB: Cycle Buddy, someone who either started the cycle with you, ovulated around the same time as you, or is planning to take a pregnancy test at about the same time as you. Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiation in patients with locally advanced rectal cancer: Final results of PRODIGE 23 phase III trial, a UNICANCER GI trial, Shortcourse radiotherapy followed by chemotherapy before TME in locally advanced rectal cancer: The randomized RAPIDO trial, Randomized phase II trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO/ARO/AIO12, Preliminary results of the organ preservation of rectal adenocarcinoma (OPRA) trial. This metaanalysis aims to explore the pCR and survival value of TNT treatment compared with standard CRT. TNT following the sequence of CRT, chemotherapy, and then surgery had a significantly higher pCR rate than the standard regimen. What does TNT mean? Veterinary TNT abbreviation meaning defined here. Other complications requiring reoperation (7). They are: Note: It takes 1 billion nanograms to make 1 gram, and 1 gram is about the weight of a small paper clip. Clinical outcomes were pCR, diseasefree survival (DFS), overall survival (OS), local recurrencefree survival (LRFS), distant metastasisfree survival (DMFS), and R0 resection rate. Weiwei Xiao, Email: nc.gro.ccusys@wwoaix. 5. the rate of early toxicity of neoadjuvant treatment according to the NCI CTCAE (version 3.0), 6. the rate of postoperative complications, 7. the rate of late toxicity according to the RTOG/EORTC scale, 8. the rate of complete pathological response, {"type":"clinical-trial","attrs":{"text":"NCT02533271","term_id":"NCT02533271"}}NCT02533271, 3. incidence of acute toxicities during radiation or chemotherapy. de CamposLobato LF, Geisler DP, da Luz Moreira A et al. Cardiology TNT abbreviation meaning defined here. Test your vocabulary with our 10-question quiz! Bujko K, Nowacki MP, NasierowskaGuttmejer A et al. Last reviewed by a Cleveland Clinic medical professional on 03/17/2022. Some people may need follow-up testing and additional medical care because of continuing symptoms or concerns, while others may be well enough to go home. For the most part, heart attacks are unpredictable and that means you cant prepare for this test. Lessons learned from a proposed randomized trial of watchandwait treatment of rectal cancer, Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: Initial results of the German CAO/ARO/AIO04 randomised phase 3 trial. 2,4,6-Trinitrotoluene is a yellow, odorless, solid manufactured compound that does not occur naturally in the environment. 5. Disclosures of potential conflicts of interest may be found at the end of this article. TNT is a promising treatment for with LARC and has been explored in previous singlearm trials, albeit with small sample sizes. In total, 2,881 potential studies were included after removing 1,993 duplicates, 2,578 were excluded from title and abstract screening, 303 studies were considered eligible for fulltext assessment, 289 fulltext articles were excluded, 146 studies were excluded because they were not randomized control trials, 62 lacked relevant intervention or endpoints, 54 studies were excluded as they were reviews, and 12 studies were excluded because of no available results, and our efforts were unsuccessful in contacting the authors for further data. Forest plots for pathologic complete response. Sun Yatsen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, For the primary endpoint pCR percentage, eight trials were analyzed with a total of 2,196 patients. Why do I need a TVT or TOT procedure? made similar comparisons in the OPRA trial [33], where they reported that patients treated with CRT followed by systemic chemotherapy increased the chances of sphincter perseveration compared with patients who receive systemic chemotherapy followed by CRT. Troponin T does exist in other types of muscle, but the amounts are very limited. Our website services, content, and products are for informational purposes only. First, although eight highquality trials were included, only 2,196 patients were analyzed. In general, shortcourse radiotherapy is preferred in Northern Europe, whereas longcourse radiotherapy has more support in the U.S. and other European countries [36]. Guangzhou Regardless of the above limitations, this metaanalysis comprehensively determined the role of TNT. People's Republic of China, 4 Abbreviation > Term Word in meaning Term > Abbreviation What does TNT Stand For in Medical & Science ? CNT . The practitioner's primary taxonomy code is 344600000X. We found that the overall pCR rate may be improved with TNT compared with standard treatment (OR, 1.77; 95% CI, 1.282.45; p=.0005), which is consistent with Petrelli's study. Lab results below the 99th percentile mean normal function. Get the top TNT abbreviation related to Medical. If your results are higher than 99% of the expected value (and the margin for precision), that indicates heart muscle damage. High-sensitivity tests measure troponin levels in nanograms per liter (ng/L). Exposure (radiation): a measure of ionization in air caused by x-rays or gamma rays only. (2018). The higher the troponin levels, the more troponin specifically TnI and TnT thats been released into the bloodstream and the higher the likelihood of heart damage. 2D) and the longcourse radiotherapy subgroup (OR, 1.48; 95% CI, 0.762.88; p=.25; Fig. Home Remedies for Heart Pain: What Works? Normally, troponin stays inside your heart muscles cells, but damage to those cells like the kind of damage from a heart attack causes troponin to leak into your blood. The Troponin T in your heart muscle also has a slightly different structure, which doesn't occur anywhere else in your body. Cercek A, Roxburgh CSD, Strombom P et al. 2003 by Saunders, an imprint of Elsevier, Inc. The https:// ensures that you are connecting to the Policy. TnI levels are typically considered elevated if theyre above 40 ng/L in a high-sensitivity test. GUEST 1 OVERVIEW: Dr Peter A. McCullough brings truth to the world and fight battles against censorship and reprisal. Treated conservatively (15), Anastomotic dehiscence requiring reoperation (4). McGraw-Hill Concise Dictionary of Modern Medicine. Mariathas M, et al. In our study, shortcourse preoperative radiotherapy combined with chemotherapy showed a significantly improved pCR rate than the standard CRT regimen (OR, 1.91; 95% CI, 1.352.70; p=.0003). These proteins are released when the heart muscle has been damaged, such as occurs with a heart attack. Future studies need to determine the optimal chemotherapy start time after shortcourse radiotherapy completion, as well as the ideal regimen and chemotherapy cycle before surgery. What is CNT meaning in Medical? A pressure injury is soft tissue damage that occurs as a result of unrelieved force on a localized area of skin and underlying tissue, causing a reduction in blood supply and subsequently, cell death. In three studies [20, 25, 29], shortcourse radiotherapy (55 Gy) was the selected regimen (Table1). 4). A sensitivity analysis was performed by removing each study in turn to establish the extent to which they contributed to the overall result. A liter is about 1/4 gallon, and it takes 1,000 milliliters to make a liter. noun The level of productivity of a clinical laboratory. Heterogeneity among the studies was quantified using Cochran's Qstatistic and I2 statistic. Theyll also look for any changes on an electrocardiogram (ECG or EKG), an electrical tracing of your heart. What does TNT abbreviation stand for? Imaging Lesions are lobular, well-delineated, hypointense on T1-weighted MRI and hyperintense on T2; . Suggest. TNT: a high explosive derived from toluene; it sometimes causes poisoning in those who work with it, marked by dermatitis, gastritis, abdominal pain, vomiting, constipation, and flatulence. Efficacy of high-sensitivity troponin T in identifying very-low-risk patients with possible acute coronary syndrome. However, damage to certain types of muscle cells can cause more troponin to escape into your blood. Newer, high-sensitivity tests can often detect even the tiny amounts of troponin in your blood that happen normally. Department of Oncology, Section II, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yatsen University, Patients treated with CRT+CT (OR, 1.76; 95% CI, 1.202.57; p=.004; Fig. To make life after cancer the best it can be that is our goal. 2002 by The McGraw-Hill Companies, Inc. TMT Abbreviation for tarsometatarsal. Some of the other conditions that can cause high troponin levels include the following: Because this test almost always happens in a hospital setting, it's unlikely that you'll need to call your doctor. Embase, PubMed, Web of Science, the Cochrane Library, and other sources were comprehensively searched up to July 15, 2020. Time to Next Treatment. Abbreviation: RCT, randomized control trial. Recent Examples on the Web For three years during the Second World War, Plum Brook manufactured explosives, namely trinitrotoluene (TNT), dinitrotoluene (DNT), and pentolite. But they arent always the optimal test because they arent sensitive enough to detect every attack. These tests may be repeated several times over a 24-hour period to look for changes. Risk of bias was performed by two investigators (S.L. In the TNTlike studies (OR, 1.31; 95% CI, 0.842.06; p=.24; Fig. Performance & security by Cloudflare. Get the top TNT abbreviation related to Cardiology. Some versions of this test can only detect one type of troponin, while others can detect both. Although the standard treatment models have resulted in tumor downstaging, improved quality of life, and lowered rates of local disease recurrence [3], pathologic complete response (pCR) is only achieved in 10%30% of patients with LARC using neoadjuvant CRT, with a high rate of distant metastasis (DM) also remaining in such patients, seriously threatening their life [4]. People's Republic of China, 5 20+ meanings of CNT abbreviation related to Medical: Medical. High troponin levels can be indicators of other heart conditions or illnesses, too. In comparative studies of the R0 resection rate, the intentiontotreat population was the one that could be resected; thus, only four studies were included [18, 24, 25, 31]. Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRIdefined poorrisk rectal cancer: A phase 2 trial, Neoadjuvant sandwich treatment with oxaliplatin and capecitabine administered prior to, concurrently with, and following radiation therapy in locally advanced rectal cancer: A prospective phase 2 trial. Preferred reporting items for systematic reviews and metaanalysis flowchart. Second, because of a lack of individual patient data, some analysis were not feasible, including subgroup analysis stratified by clinical stage and the distance between the tumor and the anal verge, and comparison of patients compliance to the treatment strategies. verb To transfer data regardless of format and type to a specific locatione.g., to another computer or peripheral device (e.g., a printer). 2,4,6-Trinitrotoluene is a yellow, odorless solid that does not occur naturally in the environment. Lifestyle changes and treatment can help improve your heart health as well as your quality of life. In other labs, whats considered normal may differ for men and women. NT. All eight trials (100%) described adequate random sequence generation and all eight (100%) had adequate treatment allocation concealment. There are two types of troponin that are more detectable after heart muscle damage, which use the letters I and T to tell them apart. Patients and care providers were blinded in seven trials (87.5%), and seven trials (87.5%) blinded the outcome assessment process. An ongoing phase II trial ({"type":"clinical-trial","attrs":{"text":"NCT03840239","term_id":"NCT03840239"}}NCT03840239) in China is evaluating whether two cycles of chemotherapy (CAPOX) before, during, and after longcourse radiotherapy will improve o sphincter preservation rates [52]. Parenteral nutrition provides liquid nutrients, including carbohydrates, proteins, fats, vitamins, minerals and electrolytes. Further analysis are needed when the data is available. Dr. GarciaAguilar et al. Seven aspects were assessed: random sequence generation, allocation sequence concealment, blinding of participants and personnel, blinding of the outcome assessment, incomplete outcome data, selective reporting, and other biases. Vote. U.S. National Library of Medicine | MedlinePlus. TNT may help improve the pCR rate, increase DFS and OS, and reduce the risk of DM, compared with standard neoadjuvant CRT among patients with LARC. The authors indicated no financial relationships. Troponin levels in the blood are. Shah ASV, et al. Taking a closer look at the treatment strategies reveals the importance of the interval between the completion of CRT and surgery on pCR. If the troponin level is high enough, it's a clear indicator of heart damage. Acting quickly when you suspect a heart attack is coming on can greatly improve your chances for survival. Preoperative conventional chemoradiotherapy versus shortcourse radiotherapy with delayed surgery for rectal cancer: Results of a randomized controlled trial, Shortcourse preoperative radiotherapy with immediate surgery versus longcourse chemoradiation with delayed surgery in the treatment of rectal cancer: A systematic review and metaanalysis, Shortcourse radiotherapy in neoadjuvant treatment for rectal cancer: A systematic review and metaanalysis, Preoperative shortcourse radiotherapy and longcourse radiochemotherapy for locally advanced rectal cancer: Metaanalysis with trial sequential analysis of longterm survival data, Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphinctersparing surgery for rectal cancer: The Lyon R9001 randomized trial, Effect of interval (7 or 11weeks) between neoadjuvant radiochemotherapy and surgery on complete pathologic response in rectal cancer: A multicenter, randomized, controlled trial (GRECCAR6). This metaanalysis found that TNT in LARC is associated with a significant improvement in overall pathologic complete response rate, diseasefree survival, overall survival, and distant metastasisfree survival compared with standard treatment. Learn why. This test involves taking a sample of your blood, analyzing it and determining if there's any troponin in the sample. Amy Shira Teitel, Discover Magazine, 19 Mar. Conception/design: Shuang Liu, GC and YHG, Weiwei Xiao, Provision of study material or patients: Shuang Liu, Lin Xiao, Collection and/or assembly of data: Shuang Liu, Ting Jiang, Shanfei Yang, Data analysis and interpretation: SL Shuang Liu Ting Jiang, Lin Xiao, Qing Liu, Manuscript writing: Shuang Liu, Ting Jiang, Lin Xiao, Final approval of manuscript: Shuang Liu, Ting Jiang, Lin Xiao, Shanfei Yang, Qing Liu, Yuanhong Gao, Gong Chen, Weiwei Xiao.

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